Translational Dementia Research Group

 

The Translational Dementia Research Group led by Dr. Caitlin Finney is focused on developing a better understanding of the causes of Alzheimer’s disease and related dementias and how to best treat them using precision medicine strategies. They also extend their research to other age-associated neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis.

Key Research Areas:

  • Genetics: Exploring the biological mechanisms underlying the risk variant APOE4
  • Diagnostics: Using machine learning to help improve Alzheimer’s diagnostics
  • In Vitro Model Development: Developing better laboratory models using patient-derived stem cells to improve translatability of preclinical research
  • Omics: Leveraging omics technologies and machine learning methods to identify biological mechanisms and treatment targets

Recent publications

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype

Developing multifactorial dementia prediction models using clinical variables from cohorts in the US and Australia

Blood-based transcriptomic biomarkers are predictive of neurodegeneration rather than Alzheimer’s disease

Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimer’s disease

The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury

 

 

NAME ROLE
Dr. Shannon Thomson Postdoctoral Research Assistant
Dr. Artur Shvetcov Visiting Academic
Ms. Isabella McEwan Honours Student
Ms. Amy Sligar Undergraduate Intern

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