
Biography
Dr. Gabriel Duette is a researcher specializing in HIV persistence and immune response mechanisms at the Westmead Institute for Medical Research, where he is part of the HIV Reservoir Research Group. He also serves as an Adjunct Lecturer at the University of Sydney’s Faculty of Medicine and Health.
His research focuses on the interplay between HIV latency, immune evasion, and how coinfections, such as tuberculosis, impact viral control. Dr. Duette’s recent work explores the potential of CD8+ T cell enhancement through structured antiretroviral treatment interruptions, with the goal of informing future strategies for a functional HIV cure.
Research interests
- HIV persistence and latency mechanisms
- Immune evasion strategies of HIV
- CD8+ T cell-mediated clearance of HIV
- Impact of coinfections, such as tuberculosis, on HIV control
- Antiretroviral treatment interruption strategies
- Virology and immune responses in infectious disease
Adjunct roles
Adjunct Lecturer | University of Sydney |
Recent publications

The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells. iScience, 27(7).
July 2024

Highly Networked SARS-CoV-2 Peptides Elicit T Cell Responses with Enhanced Specificity. ImmunoHorizons
June 2023
Additional information
University of Sydney: https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/gabriel.duette
Current grants
Delineating the viro-immunological factors contributing to transient HIV control during consecutive analytical treatment interruptions, Palmer S, Lee E, Duette G, | National Institutes of Health | 2024-2026 |
Further development of the interferon-CAR T cell strategy for reducing latent HIV infection, Cunningham A, Nasr N, Gowrishankar K, Duette G, Micklethwaite K, Westmead Institute for Medical Research/Australian Centre for HIV and Hepatitis Virology Research (ACHA) |
Affiliations
University of Sydney
Professional Associations and Organisations
Awards and recognition
Mathilde Krim Fellowship in Basic Biomedical Research (2024) |