Jacob George
Professor
Centre Director
MBBS/FRACP/PhD/FAASLD
jacob.george@sydney.edu.au

Biography
Professor Jacob George specializes in understanding the causes and mechanisms of liver disease and cancer. His research spans viral hepatitis, fatty liver disease, liver fibrosis, liver cancer epidemiology, and host genetics/immunology, with a strong focus on translating laboratory findings into clinical practice. He has led influential studies, including the identification of key genetic predictors for hepatitis C treatment response, advancing the field of personalized medicine. His work on the role of insulin resistance in fatty liver disease has shaped current therapeutic strategies.
Professor George is an active contributor to clinical trials, serves as an advisor to Hepatitis Australia and other key organizations, and oversees research for the Asian Pacific Association for the Study of Liver. He is also a Fellow of the American Association for the Study of Liver Diseases.
Research interests
Liver Disease and Cancer, Viral Hepatitis, Liver Cancer, Fatty Liver Disease (NAFLD/NASH), Hepatic Drug Metabolism, Host Genetics in Liver Disease, Liver Fibrosis and Injury, Precision Medicine, Genetics and Hepatitis C
Adjunct roles
Robert W Storr Chair of Hepatic Medicine | Sydney Medical School |
Head, Department of Gastroenterology & Hepatology | Westmead Hospital and Sydney West Local Health District |
Additional information
USYD link – https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/jacob-george.html
Current grants
National Health and Medical Research Council (NHMRC)/Ideas Grant | 2022 | Oncofetal ecosystem in advanced Hepatocellular Carcinoma: Implications for Identifying Immunotherapy response |
National Health and Medical Research Council (NHMRC)/Investigator Grant | 2021-2024 | Delineating the clinical and molecular heterogeneity of fatty liver disease to inform treatment |
Australian Centre for HIV and Hepatitis Virology Research (ACH2)/Research Support | 2021 | Development of a diagnostic assay to measure hepatitis B virus cccDNA |
Affiliations
Sydney Medical School, Westmead Hospital, Sydney Medical School, University of Sydney
Awards and recognition
2013 - Westmead Millennium Science Prize |
2013 - Distinguished Professor Award, University of Sydney |
2014 - STREP Grant SRP 08-03 awarded by Cancer Council NSW as one of the ten best projects funded by Cancer Council NSW |
2015 - NHMRC Award to Sydney Health Partners Advanced Health Research of which Storr Liver Centre is an integral part. Recognised for high quality research internationally |
2017 - Distinguished Research prize, Gastroenterological Society of Australia |
2017 - Elected to Fellowship, Australian Academy of Health and Medical Sciences |