Biography

Dr Mandeep (Manu) Singh is head of the Clonal Evolution in Autoimmunity Laboratory at the Westmead Institute for Medical Research. His work focuses on applying cellular genomics and immunogenomics to understand how pathogenic lymphocytes drive autoimmune disease.

Manu completed a B.Sc. (Hons) from the University of Otago and a PhD at the Australian National University studying T cell tolerance. He then undertook post-doctoral studies at the Garvan Institute, Sydney, and Weill Cornell Medicine, New York, where he developed single cell genomic methods to investigate the role of somatic mutations in autoimmune disease pathogenesis.

His current research develops and applies high-resolution single cell approaches to characterise the evolution of pathogenic immune cells within affected tissues across a range of human autoimmune diseases. His work centres on how somatic driver mutations, particularly those associated with lymphoma and leukaemia, shape lymphocyte behaviour and contribute to immune tolerance failure in autoimmune disease.

Adjunct roles

Recent publications

Detecting Somatic Mutations in Rare Clones using Single Cell Multi-Omics

October 2025

Summary

Rhys Gillman; Sonam Dudka; Jerome Samir; Raymond Louie; Chris Goodnow; Fabio Luciano; Mandeep Singh; Matt A. Field

 

DOI: 0.1101/2025.10.30.685685

Refractory coeliac disease or something else?

October 2025

Summary

McKelvie P; Singh M; Iser DM; Prince HM; Bazargan MA; Luciani F; Goodnow C; Tye-Din JA

 

DOI: 10.1016/j.pathol.2025.08.004

Lymphoma driver mutations at the root of somatic evolution of nerve-damaging autoantibodies in myelin associated glycoprotein neuropathy.

September 2025

Summary

Kelly S; Singh M; Russell A; Jackson KJL; Peters TJ; Carr A; Kelleher AD; Field M; Silsby M; Suan D et al.

 

DOI: 10.1016/j.jaut.2025.103474

The Somatic Mosaicism across Human Tissues Network.

July 2025

Summary

Coorens THH; Oh JW; Choi YA; Lim NS; Zhao B; Voshall A; Abyzov A; Antonacci-Fulton L; Aparicio S; Ardlie KG et al.

 

DOI: 10.1038/s41586-025-09096-7

Expanded T cell clones with lymphoma driver somatic mutations accumulate in refractory celiac disease

May 2025

Summary

Mandeep Singh; Raymond H. Y. Louie; Jerome Samir; Matthew A. Field; Claire Milthorpe; Thiruni Adikari; Joseph Mackie; Ellise Roper; Megan Faulks; Katherine J. L. Jackson et al.

DOI: 10.1126/scitranslmed.adp6812

 

Additional information

ORCID: https://orcid.org/0000-0002-6998-3805

LinkedIn: https://www.linkedin.com/in/manu-singh-976169242/

Projects:

• Tracking the evolution of pathogenic cells in celiac disease
• The role of somatic driver mutations in treatment-resistant autoimmune diseases

Awards and recognition